Bernard P Roques Selected Research

Aminopeptidases

9/2015	Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.
3/2015	Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.

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Bernard P Roques Research Topics

Disease

13	Pain (Aches) 01/2018 - 03/2002
7	Hyperalgesia 01/2017 - 03/2002
5	Neuralgia (Stump Neuralgia) 10/2016 - 04/2012
5	Paralysis (Palsy) 07/2009 - 10/2003
4	Hypertension (High Blood Pressure) 08/2012 - 05/2004
4	Botulism 08/2005 - 10/2003
3	Neoplasms (Cancer) 01/2017 - 02/2004
2	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 01/2021
2	Chronic Pain 10/2016 - 02/2007
2	Inflammation (Inflammations) 12/2012 - 07/2002
2	Osteosarcoma (Osteogenic Sarcoma) 11/2009 - 10/2008
2	Opioid-Related Disorders (Opiate Addiction) 10/2006 - 02/2002
2	Acquired Immunodeficiency Syndrome (AIDS) 12/2005 - 12/2005
2	Substance-Related Disorders (Drug Abuse) 03/2002 - 02/2002
1	Amyloid Plaque 01/2021
1	Constipation 01/2021
1	Respiratory Insufficiency (Respiratory Failure) 01/2021
1	Memory Disorders (Memory Loss) 01/2021
1	Mental Disorders (Mental Disorder) 01/2018
1	Cancer Pain 01/2017
1	Acute Pain 10/2016
1	Essential Hypertension 08/2012
1	Atherosclerotic Plaque (Atheroma) 04/2012
1	Atherosclerosis 04/2012
1	Neoplastic Processes 11/2009
1	Fibrosarcoma 11/2009
1	Herpes Simplex 01/2009
1	Intraoperative Complications 01/2009
1	Postoperative Pain 01/2009
1	Surgical Wound 01/2009
1	Infections 07/2006
1	Virus Diseases (Viral Diseases) 07/2006
1	Nervous System Diseases (Neurological Disorders) 12/2005
1	AIDS-Related Complex (ARC) 12/2004

Drug/Important Bio-Agent (IBA)

11	Opioid Analgesics (Opioids)IBA 01/2018 - 02/2002
11	Neprilysin (Neutral Endopeptidase)IBA 01/2017 - 02/2003
11	EnkephalinsIBA 01/2017 - 02/2002
9	Analgesics (Analgesic Drugs)IBA 01/2017 - 03/2002
8	Morphine (MS Contin)FDA LinkGeneric 01/2021 - 02/2002
6	Opioid Receptors (Opioid Receptor)IBA 01/2018 - 10/2008
6	EnzymesIBA 01/2017 - 02/2004
5	Proteins (Proteins, Gene)FDA Link 07/2009 - 06/2004
4	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)IBA 01/2021 - 05/2004
4	Metalloproteases (Metalloproteinases)IBA 09/2015 - 10/2003
4	Opioid Peptides (Opioid Peptide)IBA 07/2014 - 03/2002
3	Peptides (Polypeptides)IBA 01/2021 - 04/2012
3	PL265IBA 01/2017 - 03/2015
3	Peptide Hydrolases (Proteases)FDA Link 12/2012 - 06/2004
3	firibastatIBA 08/2012 - 05/2004
3	Antihypertensive Agents (Antihypertensives)IBA 08/2012 - 05/2004
3	Acetylcholine (Acetylcholine Chloride)FDA Link 07/2009 - 10/2003
2	delta Opioid Receptors (delta Opioid Receptor)IBA 10/2016 - 01/2009
2	mu Opioid Receptors (mu Opioid Receptor)IBA 10/2016 - 01/2009
2	Opiate AlkaloidsIBA 10/2016 - 10/2008
2	Leucine EnkephalinIBA 10/2016 - 09/2015
2	AminopeptidasesIBA 09/2015 - 03/2015
2	Pharmaceutical PreparationsIBA 03/2015 - 10/2006
2	Gabapentin (Neurontin)FDA LinkGeneric 03/2015 - 10/2008
2	RB 101 (RB101)IBA 04/2014 - 01/2009
2	CD13 Antigens (Alanine Aminopeptidase)IBA 12/2012 - 04/2012
2	Angiotensin IIIIBA 08/2012 - 04/2005
2	CannabinoidsIBA 04/2012 - 10/2006
2	Messenger RNA (mRNA)IBA 01/2009 - 12/2004
2	NeurotoxinsIBA 08/2005 - 06/2004
1	Amyloid (Amyloid Fibrils)IBA 10/2022
1	AntibodiesIBA 10/2022
1	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	BMS-986122IBA 01/2021
1	Narcotic Antagonists (Opioid Antagonists)IBA 01/2017
1	Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA 01/2017
1	LigandsIBA 10/2016
1	Methionine EnkephalinIBA 09/2015
1	DisulfidesIBA 09/2015
1	Formaldehyde (Formol)FDA Link 04/2014
1	ThiorphanIBA 12/2012
1	ubenimexIBA 12/2012
1	ProdrugsIBA 08/2012
1	Contrast MediaIBA 04/2012
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 04/2012
1	oxidized low density lipoproteinIBA 04/2012
1	Matrix Metalloproteinases (MMPs)IBA 04/2012
1	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 04/2012
1	SodiumIBA 02/2010
1	A-317491IBA 11/2009
1	Anesthetics (Anesthetic Agents)IBA 01/2009
1	Remifentanil (Ultiva)FDA Link 01/2009
1	proenkephalinIBA 01/2009
1	cyprodimeIBA 10/2008
1	Dronabinol (THC)FDA LinkGeneric 10/2006
1	AcidsIBA 07/2006
1	Monoclonal AntibodiesIBA 07/2006
1	vpr Gene ProductsIBA 12/2005
1	Cholinergic Agents (Cholinergics)IBA 08/2005
1	Clathrin Heavy ChainsIBA 12/2004
1	TubulinIBA 12/2004

Therapy/Procedure

3	Oral Administration 10/2016 - 10/2008
1	Ligation 10/2016
1	Analgesia 04/2014
1	Anesthesia 01/2009